Pertuzumab combined with trastuzumab, and docetaxel revealed comparable survival outcomes with previous studies of patients with metastatic breast cancer, including the CLEOPATRA trial.
A real-world analysis evaluating the triplet regimen of pertuzumab (Perjeta), trastuzumab (Herceptin), and docetaxel—THP—in Korean patients with metastatic breast cancer (mBC) revealed comparable survival outcomes with previous studies, including the CLEOPATRA trial (NCT00567190).1,2
THP has become the first-line standard of care for treating patients with HER2-positive mBC as a result of findings from CLEOPATRA.2 In the current study, after a median follow-up of 28.7 months, median overall survival (OS) and progression-free survival (PFS) were 58.3 months (95% CI, 36.6-80.0) and 19.1 months (95% CI, 16.2-21.9), respectively.
After an initial loading dose of 8 mg/kg of trastuzumab, patients received 6 mg/kg of trastuzumab, 420 mg of pertuzumab after an initial dose of 840 mg, and 75 mg/m2 of docetaxel every 3 weeks. The primary objective was to evaluate survival outcomes, including median OS and PFS. Secondary objectives were to assess treatment efficacy by objective response rate (ORR) and clinical outcomes of subsequent treatment after progression.
Investigators evaluated 228 patients with mBC who received THP. In 220 patients with measurable lesions, the ORR was 86.8% with a 17.7% complete response (CR) rate (n = 39/220; FIGURE1).
Read More: https://www.targetedonc.com/view/real-world-analysis-of-thp-in-mbc-shows-similar-survival-safety-outcomes-to-cleopatra-trial