NIH Awards $9.7 Million to Advance the Use of All of Us Research Program Dataset

November 21, 2023

Awards support 26 two-year projects on a broad range of disease areas funded across NIH

The National Institutes of Health’s All of Us Research Program and 10 partner Institutes, Centers, and Offices have funded 26 research projects to support novel analyses and tool development using All of Us’ data. The two-year awards advance impactful research in high-priority mission areas of the NIH.

“We are maximizing the contributions our participants make to advance research by supporting the development of world-class tools that can be used to explore the data and accelerate medical research,” said Sheri Schully, PhD, deputy chief medical and scientific officer. “This work would not be possible without the NIH-wide support we have received in building a research platform capable of powering countless discoveries.”

Projects include investigations on heart disease risk factors, chronic pain, intersectional mental health challenges, genetic risk factors for different cancers, and more. Additionally, some of these awards have a focus on research methods – either testing novel uses of existing methods, or developing new models and tools for data analysis. After the award period, these tools will be made available to All of Us researchers through the Researcher Workbench. 

The awards expand All of Us’ Extramural Program to Advance Research (EPAR). In 2022, All of Us sponsored 25 research teams through supplemental funding to integrate All of Us data in their currently funded research projects. Together, EPAR awardees are helping to build a network of investigators nationwide who share best practices, solve problems, and form collaborations through the All of Us Researcher Workbench. All of Us looks to this group to provide feedback on ways to improve the utility of its scientific resources, tools, and data. 

“Since launching the Researcher Workbench three years ago, we have continuously added new data and features to help researchers advance our understanding of health and disease,” said Schully. “Through EPAR, we are stimulating impactful contributions to medical research.”

About 8,000 researchers are registered to use the All of Us Researcher Workbench and the platform has supported more than 215 peer-reviewed publications, in addition to the 7,600 ongoing projects. 

Funding for the awards, listed below, was provided by All of Us, the National Eye Institute, National Heart, Lung and Blood Institute, National Human Genome Research Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Drug Abuse, National Institute of Mental Health, National Institute on Minority Health and Health Disparities, National Library of Medicine, Office of Behavioral and Social Sciences Research, and the Office of Data Science Strategy.

Awardee Institution	Principal Investigator	Project Title	Managing Institute
Brigham and Women’s Hospital	Karen H. Costenbader	Elucidating Social Determinants And Mental Health Needs To Achieve Equity In Rheumatic Disease Care	NIAMS
Fred Hutchinson Cancer Center	Burcu Frances Darst	Germline Genetics And Risk Of Prostate Cancer In Diverse Populations From The All of Us Research Program	NCI
Henry Ford Health and  Michigan State University Health Sciences	Hongsheng Gui	Assembly And Re-Alignment of HLAGenomic Region and its Implication for Fine-Mapping Suicidality in African Descent Population	NIMH
Icahn School of Medicine at Mount Sinai	Samira Asgari	Identifying Genetic and Sociodemographic Determinants of Susceptibility to Infectious Diseases in Diverse Population Groups	NIMHD
Johns Hopkins University	Casey Overby Taylor	Real-World Data Estimates of Racial Fairness with Pharmacogenomics-Guided Drug Policy	NIMHD
Marquette University	Astrida Seja Kaugars	Examining the Associations Between Women’s Experiences with Gender-Based Discrimination and Their Mental and Physical Health: an Intersectional Analysis	NIMH
Mayo Clinic Rochester	Alexej Abyzov	Discovering and Analyzing Development and Age-Associated CNAS in the All of Us Cohort	NIA
Temple University	Lin Zhu	Linking Social-Behavior Contextual Factors and Allostatic Load to Chronic Diseases in Diverse Asian Americans: A Socioecological Approach to Advancing Precision Medicine and Health Equity	NIMHD
University of Arizona	Jason Hansen Karnes	Discovery of Immunogenomic Associations with Disease and Differential Risk Across Diverse Populations	NHLBI
University of California Los Angeles	Elior Rahmani	Subtyping Complex Phenotypes via Contrastive Learning by Leveraging Electronic Health Records	NHGRI
University of California, San Diego	Rodney Allanigue Gabriel	Predictive Models for Opioid Use Disorder Using Genomic, Social, and Clinical Factors	NIDA
University of California, San Diego	Sally Liu Baxter	PAGE-G: Precision Approach Combining Genes and Environment in Glaucoma	NEI
University of Chicago	Briseis A. Aschebrook-Kilfoy	Investigation of the Social Context and Physical Environment on Cardiovascular Disease Disparities in the All of Us Research Program	NHLBI
University of Florida	Matthew James Gurka	Metabolic Syndrome Severity in All of Us: Relationship with Social Determinants of Health and with Long-Term Risk for Cardiovascular Disease	NHLBI
University of Florida	Caitrin W. McDonough	Hypertension Prediction and Identification in All of Us	NHLBI
University of Maryland Baltimore	Sally Nneoma Adebamowo	Leveraging Pleiotropy to Develop Polygenic Risk Scores for Cardiometabolic Diseases	NHLBI
University of Maryland Baltimore	Jeffrey R. O’Connell	Elucidating the Ancestry-Specific Genetic and Environmental Architecture of Cardiometabolic Traits Across All of Us Ethnic Groups	NHLBI
University of Miami School of Medicine	Matthew Christopher Danzi	Creating an Advanced Multi-Ancestral Resource and Tools For Short Tandem Repeat Analysis in the All of Us Researcher Workbench	NHGRI
University of Minnesota	Rui Zhang	Mining Minority Enriched All of Us Data For Innovative Ethnic Specific Risk Prediction Modeling	NIMHD
University of Pittsburgh	Ariadne M. Letra	Leveraging All of Us Data to Unravel the Interconnectedness Between Dental and Systemic Disease	NIDCR
University of Wisconsin-Madison	Qiongshi Lu	Characterizing Pervasive Biases in Genome-Wide Association Study Using Family Health History as Proxy Phenotypes	NIA
Vanderbilt University Medical Center	Srishti Nayak	Investigating the Medical Phenome of Speech-Language Traits: Risk, Resilience, and Opportunities for Intervention	NIDCD
Vanderbilt University Medical Center	Qingxia Chen	DARSaW: Developing, Assessing, and Refining Synthetic Sampling Weights to Improve Generalizability of the All of Us Research Program Data	NIMHD
Vanderbilt University Medical Center	Evan L. Brittain	Impact of Physical Activity, Sleep, and Genetic Background on Cardiovascular Risk in the All of Us Research Program	NHLBI
Washington University	Emma Covey Johnson	Using Genomics and Extensive Phenotyping to Dissect the Relationships Between Substance Use Disorders and Chronic Pain	NIDA
Weill Medical Coll of Cornell Univ	Mark G. Weiner	SMILE-PD: Similarity Matching in Longitudinal Electronic Patient Data	NLM